10th January 2012

The New Diamond Age

Recent decades have seen some modest successes. Starting in the 1950s, engineers managed to produce tiny crystals for industrial purposes - to coat saws, drill bits, and grinding wheels. But this summer, the first wave of gem-quality manufactured diamonds began to hit the market. They are grown in a warehouse in Florida by a roomful of Russian-designed machines spitting out 3-carat roughs 24 hours a day, seven days a week. A second company, in Boston, has perfected a completely different process for making near-flawless diamonds and plans to begin marketing them by year’s end. This sudden arrival of mass-produced gems threatens to alter the public’s perception of diamonds - and to transform the $7 billion industry. More intriguing, it opens the door to the development of diamond-based semiconductors.

9th January 2012

To Know, But Not Understand

In 1963, Bernard K. Forscher of the Mayo Clinic complained in a now famous letter printed in the prestigious journal Science that scientists were generating too many facts. Titled Chaos in the Brickyard, the letter warned that the new generation of scientists was too busy churning out bricks — facts — without regard to how they go together. Brickmaking, Forscher feared, had become an end in itself. “And so it happened that the land became flooded with bricks. … It became difficult to find the proper bricks for a task because one had to hunt among so many. … It became difficult to complete a useful edifice because, as soon as the foundations were discernible, they were buried under an avalanche of random bricks.”

The Epic Struggle to Tunnel Under the Thames

Today, engineers deal with treacherous ground by pressurizing their workfaces (though that solution still leaves tunnelers vulnerable to the problems that come from working in high-pressure environments, including bone-rot and even the bends). In the early 19th century, such measures were still decades away. The first men to attempt a tunnel beneath the Thames—gangs of Cornish miners brought to London in 1807 by businessmen banded together as the Thames Archway Company—had little to guide them.

3rd January 2012

King of the Cosmos

A profile of Neil deGrasse Tyson.

Tyson spreads himself so wide for two reasons. One is that there’s so much in the sky to talk about. The other reason is down here on earth. For all the spectacular advances American science has made over the past century—not just in astrophysics but in biology, engineering, and other disciplines—the best days of American science may be behind us. And as American science declines, so does America. So here, in the dark, under the stars, Tyson is going to try to save the future, one neck cramp at a time.

21st December 2011

A Thing or Two About Twins

They have the same piercing eyes. The same color hair. One may be shy, while the other loves meeting new people. Discovering why identical twins differ—despite having the same DNA—could reveal a great deal about all of us.

9th December 2011

Out-of-Body Experience: Master of Illusion

It is not every day that you are separated from your body and then stabbed in the chest with a kitchen knife. But such experiences are routine in the lab of Henrik Ehrsson, a neuroscientist at the Karolinska Institute in Stockholm, who uses illusions to probe, stretch and displace people’s sense of self. Today, using little more than a video camera, goggles and two sticks, he has convinced me that I am floating a few metres behind my own body. As I see a knife plunging towards my virtual chest, I flinch. Two electrodes on my fingers record the sweat that automatically erupts on my skin, and a nearby laptop plots my spiking fear on a graph.

5th December 2011

Out of Thin Air

The lowest point of his career occurred at the highest point he raced. Mexico City is surrounded by mountains and is over 7,000 feet above sea level. That the altitude would have an impact on the Games was predicted. Clarke had raised concerns himself, but had been told by the Australian sports authorities that whingeing was bad sportsmanship. Since those Olympics, however, scientists have stepped up their investigation into the link between athletic performance and altitude. This research, in turn, raises some deceptively simple questions, which have bafflingly complex answers. What counts as sport? What is its purpose: what are the rules designed to achieve, designed to measure? Where does sport end, and science and technology begin? The difficulty of these matters, and the lack of any clear principles, have made sporting authorities at times appear capricious and contradictory.

28th November 2011

Grey Matters

While we are alive, it is the seat of our intelligence, the centre of all that is unique about ourselves. After death, however, it suffers a precipitous drop-off in usefulness. It cannot, after all, be transplanted like the liver, kidney or heart. Even the ancient Egyptians, who took great pains to remove and store most internal organs prior to mummification, declined to keep the brain. Instead, they preferred to insert a long, slightly hooked tool through the nose of the body and swirl it around like a swizzle stick in a cocktail before tipping the deceased’s head forward and pouring the remnants out. To them the brain was the dregs of life.

Considering such hostile treatment, it is no wonder that disembodied brains have taken to huddling together in subterranean repositories known as brain banks. These collections of brains have, over the past 100 years, become essential to medical research. This is the story of three such banks – one of the past, one of the present and one of the future. Each one tells a story of our changing relationship to these highly valuable, infinitely mysterious, and quease-inducing organs.

17th November 2011

The Mouse Trap

At the National Institute on Aging, as at every major research center, the animals are grouped in plastic cages the size of large shoeboxes, topped with a wire lid and a food hopper that’s never empty of pellets. This form of husbandry, known as ad libitum feeding, is cheap and convenient since animal technicians need only check the hoppers from time to time to make sure they haven’t run dry. Without toys or exercise wheels to distract them, the mice are left with nothing to do but eat and sleep—and then eat some more.

That such a lifestyle would make rodents unhealthy, and thus of limited use for research, may seem obvious, but the problem appears to be so flagrant and widespread that few scientists bother to consider it. Ad libitum feeding and lack of exercise are industry-standard for the massive rodent-breeding factories that ship out millions of lab mice and rats every year and fuel a $1.1-billion global business in living reagents for medical research. When Mattson made that point in Atlanta, and suggested that the control animals used in labs were sedentary and overweight as a rule, several in the audience gasped. His implication was clear: The basic tool of biomedicine—and its workhorse in the production of new drugs and other treatments—had been transformed into a shoddy, industrial product. Researchers in the United States and abroad were drawing the bulk of their conclusions about the nature of human disease—and about Nature itself—from an organism that’s as divorced from its natural state as feedlot cattle or oven-stuffer chickens.

Part 2, part 3.

7th November 2011

Unfrozen

Shortly after 6 p.m. on a drizzling, dreary November day in 2010, two men dressed in green surgical scrubs opened the door of the Iceman’s chamber in the South Tyrol Museum of Archaeology in Bolzano, Italy. They slid the frozen body onto a stainless steel gurney. One of the men was a young scientist named Marco Samadelli. Normally, it was his job to keep the famous Neolithic mummy frozen under the precise conditions that had preserved it for 5,300 years, following an attack that had left the Iceman dead, high on a nearby mountain. On this day, however, Samadelli had raised the temperature in the museum’s tiny laboratory room to 18°C—64°F.

With Samadelli was a local pathologist with a trim mustache named Eduard Egarter Vigl, known informally as the Iceman’s “family doctor.” While Egarter Vigl poked and prodded the body with knowing, sometimes brusque familiarity, a handful of other scientists and doctors gathered around in the cramped space, preparing to do the unthinkable: defrost the Iceman. The next day, in a burst of hurried surgical interventions as urgent as any operation on a living person, they would perform the first full-scale autopsy on the thawed body, hoping to shed new light on the mystery of who the Iceman really was and how he had died such a violent death.

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